γδ T cells

T Cell Type TCR Type Recognized Antigens MHC Molecule Type
Classical helper and cytotoxic T cells αβ TCRs Peptides Class I or Class II MHC
Semi-invariant T cells αβ TCRs (limited diversity) Lipid antigens or small organic molecules Nonclassical MHC

its antigen recognition is fundamentally different than that of αβ T cells
其抗原识别与αβT细胞有着根本的不同

Later work showed that most or all γδ T cells recognize antigens directly, like antibodies, and that the MHC molecules are not an obligatory component of γδ T cell antigens.

TCR and CD3 Molecules

Isolation and Characterization of αβ and γδ TCRs

αβ和γδTCR的分离与表征